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AR affects approximately 10-40% of people globally [4], damaging labor productivity and causing economic losses of 30 to 50 billion euros per year in the European Union [5]

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Heme oxygenase (HO) has three distinct isoenzymes, respectively namely heme oxygenase 1 (HO-1), heme oxygenase 2 (HO-2) and heme oxygenase 3 (HO-3) [6]

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